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We think that the [neurons influence] on intervertebral disc degeneration is not only limited to the occurrence of pain, but also intervertebral disc degeneration itself, said Ximing Xu, professor in the Department of Orthopedic Surgery in Changzheng Hospital, and co-lead author of the study

Furthermore, determining the time of circulation, which is critical for drug efficacy, is difficult (171)

In addition, either apoptosis or necroptosis can be initiated by receptors such as TNFR and Fas, depending on the intracellular state of the target cell

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