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After exposition to inflammatory stimuli, macrophages secrete cytokines such as tumor necrosis factor (TNF), interleukins (IL), leukotrienes, and prostaglandins

As a result, it elicits a robust antitumor immune response and suppresses distant metastasis ( Figure 12C )

In controlled laboratory settings, the GHK-Cu peptide is used to investigate mechanisms involving collagen synthesis, matrix metalloproteinase modulation, nerve tissue repair signaling, and antioxidant gene upregulation