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In addition, it is necessary to consider the cut-off concentrations of bilirubin for hypobilirubinemia, below which there is a risk of developing pathological conditions

Further studies identified the dependence of ROS-induced apoptosis on the persistent activation of pro-apoptotic mitogen-activated protein kinase (MAPK) pathways (cJun N-terminal kinases [JNKs] and p38), which modulated the phosphorylation of mitochondrial pro-apoptotic and anti-apoptotic proteins [26, 27]