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It is important to note that exploration of a novel environment was not affected in the same animals, indicating that the low scores measured in both the swim test and the home-cage locomotion tests were not due to motor impairment

Studies measuring acute cognitive performance during active compound presence benefit from daily protocols, while research examining lasting neuroplastic modifications often achieve better results with spaced administration that allows consolidation between doses

Retatrutide : Phase 3 TRIUMPH-4 demonstrated 28.7% mean weight loss at 68 weeks with 12 mg dose (Phase 2 showed 24.2% at 48 weeks)

Reflecting this growing interest, a rapid proliferation of systematic reviews and meta-analyses has sought to synthesize the evidence on MCE and cognition (Basak et al., 2020