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Enrichment analysis was performed to identify significantly altered metabolic pathways

Glycometabolism in macrophages Proinflammatory M1 macrophages have higher glucose consumption and lactate release than M2 macrophages, mainly relying on aerobic glycolysis, while anti-inflammatory M2 macrophages mainly rely on oxidative phosphorylation (OXPHOS)

210,211,212 In recent studies, NIR irradiation for BBB permeability regulation was applied under infrared thermal monitoring and the head temperature was kept lower than 43 C