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Oral lycopene-rich tomato extract proved to increase the serum levels of superoxide dismutase and contribute with topical 4% hydroquinone to mMASI reduction, after 12 weeks [94]

Strategies aimed at restoring antioxidant homeostasis and limiting inflammatory oxidative stress may therefore warrant further investigation as approaches to delay onset or slow disease progression

For instance, during early influenza infection, TLR7/RIG-I signaling and M2 ion channel activity cooperatively promote potassium ion efflux and mtROS generation, activating NLRP3 to enhance IL-1/IL-18 release (Vora et al., 2021)

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