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Brodie and co-workers used a combination of Molecular Dynamics simulation data substantiated with cross-linking mass spectrometry (MS) and single molecule Frster resonance energy transfer (smFRET) data to generate an ensemble of conformational spaces of such -synuclein monomers (Mahapatra and Newberry, 2024)

K i was determined with GraphPad Prism 8 software using the mixed model inhibition

Administration of iron-clearing agents in ALS mice delays disease onset, reduces ROS production, suppresses TNF-, and extends survival by preserving motor neuron viability (352, 355)