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Single nucleotide variations in the C13orf31 gene , resulting in amino acid changes in p.C284R and p.I254V in a protein of unidentified function, play a role in the development of systemic juvenile idiopathic arthritis and are associated with heightened susceptibility to leprosy and CD (66).This suggests that individuals with IBD may have an inherent vulnerability to mitochondrial dysfunction, particularly influenced by the gut environment

& Utsumi, S

Upregulation in phenylalanine (increased PAL), tyrosine (increased TYR, HPPD), arginine/proline (increased ARG, P5CR), and glycine/serine/threonine (increased AMT, TA) metabolism serves multiple protective functions: (1) Antioxidant Production: PAL activation promotes phenolic antioxidant synthesis

MLL4 binds TET3