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Post-inflammatory hyperpigmentation happens when skin is inflamed or injured, for example because of acne, and the impacted area is left darkened and hyperpigmented despite having otherwise healed

A transient breach in the epithelial barrier leads to the resistance to colitis This study was the first direct attempt to understand how physiologic breaks in the mucosal barrier, which must occur for homeostatic regulatory T cells to develop (Figure 1), may differ from the pathological mucosal barrier defects widely implicated in promoting inflammation of the underlying lamina propria

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Before GLP-1 agonists, most weight loss medications produced 5 to 10 percent body weight reduction at best