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Symptoms of MCAS include flushing, itchy skin, low blood pressure, constipation and/or diarrhea, abdominal pain, shortness of breath, and nasal congestion.[ref] The symptoms of MCAS are driven by excess histamine and overlap with histamine intolerance

Especially in organs with a high energy demand like the liver which is responsible for the detoxifying of foreign substances for the whole body , the heart, kidneys and the brain, cells and mitochondria can be harmed

spiralis antigens can reduce the severity of colitis in a mouse model of DNBS-induced colitis, as evident from a down-regulation of IL-1 production, myeloperoxidase activity, and inducible nitric oxide synthase and an upregulation of IL-13 and TGF- production [162]

Emodin alleviates joint inflammation and bone erosion in rats with collagen-induced arthritis by inhibiting ferroptosis and degrading matrix metalloproteinases]