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BSO alone did not result in decreased cell viability, however, when used in combination with cisplatin, it sensitized the cell line, resulting in a significant decrease in cell viability when compared to cisplatin alone (Fig

5 Clinical challenges and future perspectives 5.1 Challenges of tumor heterogeneity in the ferroptosis treatment response GBM exhibits significant molecular heterogeneity, which directly affects the efficacy of ferroptosis-targeted therapies