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4 film-coated tablets Dispense enclosed Medication Guide to each patient

Data availability Further information and reasonable requests for resources and reagents should be directed to and will be fulfilled by the lead contact, Steven Laviolette ([email protected])

2.2.5 Inflammation, oxidative stress, and others Asymptomatic hyperuricemia exhibits pro-inflammatory and pro-oxidative properties that contribute to multisystem pathology

Other metabolic and urological causes to consider include: Chronic kidney disease : Metabolic syndrome and diabetes can damage kidney function, affecting the kidneys' ability to concentrate urine Hypercalcaemia : Elevated calcium levels can impair kidney concentrating ability Urinary tract infections : Particularly in women, causing frequency with dysuria (painful urination) Overactive bladder syndrome : A common condition causing urgency and frequency Benign prostatic hyperplasia : In men over 50, causing obstructive urinary symptoms Pregnancy : A common cause of urinary frequency in women of childbearing age Diabetes insipidus : A rare condition affecting water regulation Excessive fluid intake : Including caffeinated beverages and alcohol Obstructive sleep apnoea , which is more prevalent in people with obesity and NAFLD, can cause nocturnal polyuria (night-time urination) due to hormonal changes affecting fluid regulation during disrupted sleep