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Rating: 4.8118 (16 reviews)

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Description

In addition, the mechanism underlying the amelioration of heart failure is investigated, and the results reveal that the therapeutic effects of this system on cardiomyocytes and cardiac fibroblasts are mainly mediated through the cAMP/AMPK and cGMP/PKG signalling pathways

The structural modification of this peptide includes an arginine substitution at position 3 and an extended amino acid sequence, which influences receptor binding affinity and reduces susceptibility to proteolytic enzymes in controlled experimental conditions