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A recent analysis using Mendelian randomization showed that genetically predicted homocysteine levels increased the odds of NAFLD.[ref] Related article: NAFLD genes Cardiovascular disease: To answer the question of whether a modestly elevated homocysteine level is causally associated with an increased risk of cardiovascular disease, researchers again used huge genetic data sets and Mendelian randomization to determine causality

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Nonetheless, safety concerns have not emerged from the trials so far, and there are some data suggesting the oral lead-in is not necessary

MaruyamaTHiguchiTYamazakiTOkawaEAndoHOikawaOet alLevocarnitine injections decrease the need for erythropoiesis-stimulating agents in hemodialysis patients with renal anemia