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AOD-9604 is supplied as a research grade synthetic peptide reference compound intended exclusively for controlled laboratory and analytical environments

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To reconcile the opposite effects of V-ATPase dysfunction on autophagy flux in nutrient-rich versus starvation medium, we reasoned that dysfunction of the V-ATPase may have dual roles in autophagy regulation: On the one hand, it hampers vacuolar hydrolytic activities (but vacuolar proteases such as Pep4 are still partially active)

In plain terms: it targets a root cause of stubborn fat at the cellular level the metabolic brake instead of just turning up the effort you're already putting in