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Although moderate levels of ROS act as signaling molecules in cellular processes such as differentiation, proliferation, and adaptive responses [153], excessive ROS accumulation induces lipid peroxidation, protein modification, and mitochondrial DNA damage, ultimately leading to cellular senescence, apoptosis, or dysfunction [154]

Prog Brain Res 190, 145153, 10.1016/b978-0-444-53817-8.00009-8 (2011)

Sano, R