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Other studies indicate that lower serum IGF-1 concentrations are associated with reduced cognitive function, showing a negative correlation with age, disease duration, and modified Rankin Scale [134, 135], yet a positive association with more substantial declines in Minimum Mental State Examination (MMSE) scores, CSF A 1-42 /A 1-40 ratio, and diminishing recall, language fluency, attention, and numeracy function [134, 136]

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Research has demonstrated that glutamate dehydrogenase (GLUD1) is expressed at a high level in lung adenocarcinoma cells, and lysine 503 (K503) has been identified as the primary ubiquitination site of GLUD1

Chou X, Ding F, Zhang X, Ding X, Gao H, Wu Q