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Dosing & Reconstitution Guide Educational guide for reconstitution and weekly dosing Standard / Gradual Titration (3 mL = ~3.33 mg/mL total) Route: Subcutaneous injection

Circulation 2001;103:919-25

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Research Highlights Phase 1 (12 weeks): Reductions between ~2.6% and ~11.3% Phase 2 (48 weeks): Lower-dose groups reached ~9% reductions Higher-dose and titration groups achieved ~20% reductions Control groups saw ~0.4% These outcomes place Eloralintide among the strongest-performing compounds within the amylin-pathway category