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For instance, poor metabolizers are more likely than other individuals to experience drug toxicity, and less likely to gain benefit from the analgesic codeine, a prodrug which is metabolized by CYP2D6 to morphine, the active drug

LZ: Methodology, Writing review & editing

FEBS Lett 579:415420

DStruBTarget indicated that the top ten predicted proteins binding to MH were enriched in neuroactive ligand-receptor interactions and neurotransmitter receptor activity functions ( P = 1.3 10 7 ), whereas the top 10 DStruBTarget predicted proteins binding to SP were enriched in inflammation-related functions (Supplementary Table 11)