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Shaking is just as destructive as injecting the water too forcefully

Fluorescence spectroscopy studies of the binding of PREG and the related sulfated neurosteroid 3-hydroxy-5-pregnan-20-one sulfate, which differentially modulate NMDA and AMPA receptors, suggest that the differential effects of these sulfated neurosteroids on current flow may be related to their binding at the SIS2 and amino terminal domains of these receptors (178)