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Description

It was also suggested that HDAC upregulates CD80 and CD86, which induces enhanced immunogenicity of tumor cells and obliteration of tumor cells

Cell 171(6):1340-1353e14

Therefore, the host immune system creates and transcribes proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-), interleukin-1 beta (IL-1), interleukin-6 (IL-6), and interleukin-8 (IL-8), as well as chemokines such as CX3CL1 and CCL4 (Rattanasrisomporn et al