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Tobacco and Cancer Risk StoryMD Does Nicotine Pouches & ZYN Make You Poop? The Science Can Smoking Cause Constipation? Surprised? While smoking itself isn't a direct cause of constipation, nicotine can mess with your gut motility . When you quit smoking, your bowels may temporarily Think Smoking Only Affects Your Lungs? Think Again. Your digestive system takes a major hit too. Smoking can weaken your gut lining, slow down digestion, and increase the risk of ulcers and

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