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In addition to their intrinsic calcium-handling systems, mitochondria are functionally and structurally connected to the ER at specialized membrane contact sites known as mitochondria-associated membranes

Multiple classes of advanced therapies, including both monoclonal antibodies and novel oral small molecules, are now available for the treatment of moderately-to-severely active Crohns disease and ulcerative colitis, highlighted by the approvals of the first IL23p19 antagonists, selective Janus kinase inhibitors and sphingosine-1-phosphate receptor modulators

AMPA and kainate glutamate receptors are non-selective ion channels that allow both sodium and potassium to flow across the membrane