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Given that suppressing mTOR expression inhibits PNI in pancreatic cancer, we speculated whether mTOR is required for the HGF/c-Met signaling pathway to exert its promoting effects on PNI in pancreatic cancer

(11) Elena M Khvatova, Victor N Samartzev, Pavel P Zagoskin, Igor A Prudchenko, and Inessa I Mikhaleva (2003) Delta sleep inducing peptide (DSIP): effect on respiration activity in rat brain mitochondria and stress protective potency under experimental hypoxia Peptides, 2003 Feb, Volume 24 (Issue 2), Pages 307-11

They next experimented with injecting old animals with a small molecule drug that inhibits 15-PGDH activity first into the abdomen, which affects the entire body, then directly into the joint