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They also revealed the combination of favipiravir (antiviral therapeutic for SARS-CoV-2) with nicotine could successfully block 6LZG, a main active site of ACE2-S protein, suggesting the potential influence of this combination for blocking ACE2 versus SARS-CoV-2 [334]

Thereafter, the lung models were transferred to a cell incubator (37 C, 60% humidity and 5% CO 2 ) for 1 h until next exposure session

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