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H-D K, Scheinischen D, El-Tounsi I, Andreeff M

Crombie' group from American and Hong' group from Korea re-designed the benzenesulfonamido aminopyrimidine scaffold through the introduction of other substituent groups at R 1 , respectively, and got two representative inhibitors 66 and 67 that possessed a low nanomole level of inhibitory potentials [178, 179]

*Correspondence: Joseph M

The exploration and investigation of GPxs, as key enzymes that regulate ROS levels in humans, is of great significance to elucidate the relationship between GPxs and diseases, including tumors, to further understand the pathogenesis of diseases and to prevent ameliorate and even cure these diseases