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Reconstituted peptides require refrigeration and use within 3-4 weeks for optimal stability

136 In vitro studies have shown that Cu binds to HTT proteins with 1768 glutamine residues, whereas neither Fe nor Zn exhibits binding affinity

Current evidence suggests the individual peptides are generally well tolerated when used appropriately, but long-term human data on the full KLOW stack is still limited

Evaluation of two independent cohorts of patients, who received 4g/day APAP for 12 weeks, revealed an association between CD44 rs1467558 polymorphism and elevated serum ALT levels, a biomarker of hepatocellular injury [106]