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Primary ECs, in turn, are sourced either from animal tissues or patient biopsies and offer the possibility of comparing a diseased phenotype and a dysfunctional status to control cells [79, 80]

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M-cells take up large antigens, macromolecular complexes, particulates, and proteins such as ferritin and peroxidase and also intact viruses, bacteria, and protozoa through a specific and regulated process termed receptor-mediated endocytosis in which cell-surface receptors such as GP2 recognize specific antigens expressed on microorganisms that initiate transit through the cell, exocytosis, and engulfment by phagocytic subepithelial dendritic cells (Fig

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