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Figure 1 shows the steep rise in comments over the analysis period: Furthermore, January 2015 saw an average of approximately 350 comments per day on the subreddit, but by February 2019, this had increased to an average of 1,485 daily comments ( Figure 2 )

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In the canonical TGF-/Smad signaling pathway, TGF- ligands regulate key transcription factors that promote EMT through Smads protein and synergistic kinase pathway