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ISs such as azathioprine and methotrexate, priced at $20 to $40 per month, offer a more affordable alternative to biologics for moderate to severe IBD

The combination of the two can overcome the oxygen-dependent limitations of PDT, enhance the therapeutic effect of deep-seated tumors, reduce drug resistance and the risk of recurrence, and activate the immune system to improve the systemic anti-tumor effect (Cuadrado et al., 2024)

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This concerted global initiative serves as the cornerstone for assuring the quality and safety of probiotic products utilized worldwide