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These results indicate that the loss of cellular glutathione and increase in oxidative stress alters vitamin D metabolism genes and vitamin D receptors, which can predispose the body to 25(OH)VD 3 deficiency

The 2024 fusion-peptide work exists precisely because researchers recognized that native DSIPs delivery to the brain is the bottleneck, and engineered around it by fusing DSIP to a blood-brain-barrier-crossing TAT transduction domain (sequence GGGGYGRKKRRQRRR) via flexible GGGGS linkers, expressed and secreted from Pichia pastoris