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It does this by interfering with the SNARE protein complex, a crucial component in the process that allows nerve signals to tell muscles to contract

Additionally, hGH can inhibit lipoprotein lipase in adipose tissue, causing lipolysis and leading to decreases in fat cell mass (2)

The inflammatory cytokines secreted by aging cells (SASP) induce macrophage proliferation and enhance CD38-dependent NADase activity, thereby reducing the level of NAD in tissues

Overall, silymarin shows promise as a complementary therapy across various CLDs, particularly NAFLD and ALD, with evidence supporting its efficacy in improving liver enzymes and potentially aiding in histological improvements