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The mechanism involves enhanced fatty acid oxidation, improved insulin sensitivity in skeletal muscle, and, perhaps most impressively, the browning of white adipose tissue through the ERK signaling pathway

Emerging evidence highlights the multifaceted therapeutic implications of intratumoral microbiota, spanning from its diagnostic utility as a tumor-specific biomarker to its synergistic interplay with immunotherapies, with particular promise emerging through engineered bacterial interventions that precisely modulate the tumor microenvironment

Erica Di Ruggiero, Dalla Lana School of Public Health, University of Toronto, Canada