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The history and development of NF-B signaling The mammalian NF-B transcription factor family consists of five members, namely NF-B1 (p105/p50), NF-B2 (p100/p52), p65 (RELA), V-Rel reticuloendotheliosis viral oncogene homolog B (RELB), and c-REL

This occurs due to both reduced endogenous synthesis by the kidneys and the significant removal of this small, water-soluble molecule through the dialysis membrane