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Lipid-lowering properties Spinach contains saponins which are known to lower cholesterol and blood pressure because of their interactions with the surface molecules in the intestinal cell membrane, forming insoluble complexes with cholesterol, which interfere with cholesterol absorption

10.1038/s41588-022-01045-8 60 LuL.WangF.ChenJ.ZhaoC.GuoS.DongD.et al (2023)

In addition, the two mutations were not found in 600 ethnically matched normal controls