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[7] Clinicians should exercise extreme caution in advanced chronic kidney disease or sarcoidosis, tuberculosis, and other granulomatous disorders where extrarenal 1-hydroxylase activity can generate excess calcitriol and precipitate hypercalcaemia even at modest serum 25-hydroxyvitamin D concentrations

It is therefore imperative that we make a concerted effort to engage and involve more people of Hispanic origin in innovative clinical trials that would not only benefit them but would also assist us in developing treatment strategies that are most effective for a predominately Hispanic population

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To address this dilemma, enormous derivatization strategies that sulfhydryl-reactive probes sheltered thiols from oxidation were developed and coupled with fluorescence or mass spectrometry (MS) for thiol profiling