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This capacity allows them to colonize adhesion sites, including colonic crypts, goblet cells, and intestinal villi, in substantial numbers, thereby physically preventing pathogens from gaining a foothold and establishing infection (163, 192)

Consistent with P300, in vitro lactylation assays further substantiated the delactylase activity of SIRT1 (Supplementary Fig

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Additionally, hepatotoxicity is a notable concern, particularly in patients with risk factors such as alcohol consumption, obesity, and diabetes, which can exacerbate liver damage