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Emerging role of cellular senescence in the pathogenesis of oral submucous fibrosis and its malignant transformation

NFKB appears to have a novel DNA-binding structure called beta-barrel, a group of beta sheets stretching toward the target DNA

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Later, Jins group showed that the endogenous H 2 S/CSE pathway was suppressed in MCT-induced PH rats, and exogenous H 2 S reduced pulmonary artery pressure, reversed pulmonary vascular structural remolding by suppressing phosphorylation of NF-B p65 and IB MCT-treated rats (Feng et al., 2017)