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This dual action is why many clinics combine them in skinlightening infusions and why some people report a more luminous complexion after treatment

despite only modest gains in intrinsic potency, it achieves effective concentrations in vivo and delays tumor growth in xenograft models (12)

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To assess whether these molecular changes translate into tumor growth inhibition, we subcutaneously grafted LNCaP and LNCaP APIPC cells into NOD scid gamma (NOD.Cg-Prkdc scid Il2rg tm1Wjl /SzJ) mice (non-castrated for LNCaP and castrated for LNCaP APIPC )