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Regulation of the dynamic balance between pro- and anti-inflammatory immune responses is a critical factor for the successful control of MAC infection

Critical role for p53-serine 15 phosphorylation in stimulating transactivation at p53-responsive promoters

5-Amino-1MQ Capsules | Verdict 5-amino-1MQ capsules represent a potentially novel treatment of obesity, type 2 diabetes, and muscle wasting conditions

This fragmentation contributes to the broader, well-recognized challenge of high attrition from preclinical signals to clinical benefit, particularly in chronic, heterogeneous conditions where species differences, comorbidities, and polypharmacy complicate external validity (Ineichen et al., 2024)