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And Pim-1 inhibitor AZD1208 ameliorated proteinuria, glomerulonephritis, renal immune complex deposits, and serum anti-dsDNA antibody levels in mice with lupus nephritis

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70 Moreover, in tissues of PDA patients, lactylation of TFEB at lysine 91 has been identified, which prevents its ubiquitination and proteasome degradation by hindering its interaction with the E3 ubiquitin ligase WWP2, enhancing TFEB activity and autophagy flux, which promotes pancreatic cancer progression