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doi: 10.1016/j.phymed.2023.154881 257 NieJLingYJinMChenZLiuWShenWet al

This can feel like dryness, tingling, or a mild burning sensation, especially during the initial days of use

Although inhibition of PDH activity by overproducing pyruvate dehydrogenase kinase 4 in INS-1 cells did not affect GSIS [35], it is possible that PDH may play a supportive role for GSIS by providing acetyl-CoA to condense with the oxaloacetate produced by PC, to form citrate for downstream shuttles