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[45] The accumulation of neuronal and muscular ROS appears to contribute to age-associated impairments

Proven Performance Up to 95% of patients show a significant improvement in incontinence scores 2,3 Provides sustainable improvement for 12-24 months 2-10 Improves patient quality of life 2-4, 7, 11 Reinjection is effective 5 Helps improve anal asymmetry index which may be linked to increased maximum resting anal canal pressures 2 References 1

This altered metabolic profile of Gdap1 / cells correlates with a dysfunctional mitochondrial state that is likely a key factor in GDAP1 deficiency-associated cellular defects in CMT disease

Imaging cytosolic NADH-NAD(+) redox state with a genetically encoded fluorescent biosensor