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Absolute deficiency occur up to 6% of those aged 60 years and older, whereas marginal deficiency occur in close to 20% of patients in later life ( Pernicious anemia is an autoimmune gastritis resulting from the destruction of gastric parietal cells and consequent impairment of intrinsic factors secretion to bind the ingested vitamin B12

In an email, Jong-Hwei Su Pang, a professor at Chang Gung Universitys Graduate Institute of Clinical Medical Sciences, wrote that the peptide might be produced by stomach microbes, as its amino acid sequence doesnt appear in the human genome

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