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ScharfsteinJSKeaneyJFJr.SlivkaAWelchGNVitaJAStamlerJSet alIn vivo transfer of nitric oxide between a plasma protein-bound reservoir and low-molecular weight thiols

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At CIV, NO inhibits respiration by binding to its oxygen binding site and inhibiting the flow of electrons through the respiratory chain (decreasing complex activity) (Figure 5) ( FIGURE 5 NO binds to CIV at both normoxic oxygen concentrations, where CIV is primarily oxidized, and hypoxic oxygen concentrations, where CIV is primarily reduced