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Regarding the genetic component, at least 240 gene loci related to inflammatory responses (mainly in the nucleotide oligomerization domain -NOD- receptors, chemokines, cytokines), autophagy, and antimicrobial peptides seem to be associated with the predisposition and occurrence of IBD [35]

A number of recent studies have aimed to address gland regeneration after radiation damage in the mouse model by either isolating putative stem cell populations for reimplantation (Nanduri et al , 2013, 2014) or sparing the regions within the gland that are thought to harbor the stem cells (van Luijk et al , 2015)

These cultivated areas are considered unstable, as they increase and decrease annually depending on one essential element: marketing [24]