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doi: 10.1155/2014/394264

Eighteen years later, FDAs briefing document for its December 2024 advisory committee meeting put the same event into the regulatory record with more clinical detail

72 These findings suggest that subnormal ALP levels may be a useful diagnostic tool for HPP, that PLP levels may be useful in patients with a suspected diagnosis of HPP, for screening family members to detect possible heterozygotes, and to monitor response to therapy