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Landmark analysis is the recommended solution to such biases since it splits the follow-up period at a given time point

doi: 10.1016/j.advms.2017.06.006 92 MuellerD

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AKG, a TCA cycle metabolite, is a required cofactor for the histone demethylase JHDM and the DNA demethylase TET, and a reduction in Gln-dependent aKG production inhibits the activity of histone and DNA demethylases, which regulate numerous cancer-related genes 40,41