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It exists as a 32 kDa homodimer, mainly confined to the cytoplasm, with a smaller proportion in the mitochondrial intermembrane space (IMS)

Deng, & C

22 To estimate the strength of the association, univariable (binary) logistic regression models were used to calculate the odds ratio (OR)

Riboflavin supplementationby increasing intracellular FAD concentrationcan restore cofactor binding, improve protein folding and subcellular localization, and rescue enzymatic activity, an effect known as the flavin chaperoning or chemical chaperone mechanism (58)