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To test this hypothesis, we investigated the effect of IIR on muscle insulin sensitivity during moderate-intensity continuous knee-extension exercise

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It was further demonstrated that deletion of one Alox12 allele in mouse promotes lymphomagenesis in E-Myc models, and that ALOX12 missense mutations derived from human cancers lose their capabilities to oxygenate PUFA and to promote p53-mediated ferroptosis (Chu et al., 2019)